Bespoken Nanoceria: An Effective Treatment in Experimental Hepatocellular Carcinoma

Hepatocellular Carcinoma in Sheep

Preclinical studies of 166Ho-chitosan for treatment of hepatocellular carcinoma

Introduction: Recently, due to the special characteristics of 166Ho and chitosan, 166Ho-chitosan complex was developed for treatment of tumors such as hepatocellular carcinoma. This complex has been lately prepared with high radiochemical purity in our lab. The preclinical studies of the complex however should be performed to evaluate the tracer concentration in target and...

Hepatocellular carcinoma in a sheep

At necropsy of a five-year-old sheep, a pear shaped, lobular yellow-brownish mass measuring about 12 ×15 × 20 cm was found to involve the right hepatic lobe. Microscopic examination revealed two trabecularand solid patterns of neoplastic hepatocytes. In solid pattern, there were numerous tumoral giant cells thatcontain one or more large hyperchromatic bizarre-shaped nuclei scattered among clust...

New, effective treatment using proton irradiation for unresectable hepatocellular carcinoma.

In 34 hepatocellular carcinoma patients (44 lesions), proton irradiation was performed and assessed. Proton irradiation was effective for the nodular HCCin terms of tumor size reduction and histology and almost 100%local tumor control was obtained during the observation period of at least 2 years, which is still undergoing up to 4 years. This therapy is safe and has the merit of excellent QOL d...

Apatinib is effective for treatment of advanced hepatocellular carcinoma

As treatment options for hepatocellular carcinoma (HCC) are currently limited, we evaluated the efficacy and safety of oral apatinib, a VEGFR-2 inhibitor, on patients with advanced HCC. Twenty-two patients from Tianjin Medical University Cancer Institute and Hospital were enrolled for evaluation. Apatinib was administered at 500 mg/day or 250 mg/day continuously. Clinical endpoints were time to...